Hemagglutinin and a Future Cure for Influenza

Final Project: Hemagglutinin Summary Hemagglutinin is a membrane protein found in influenza virus. The focus of this project is on the hemagglutinin subtype H1, which is the H1 subtype involved in the 1918 Spain influenza. This project focuses on explaining the structure and function of proteins, trying to accurately describe the intermolecular interactions between proteins and host cell membranes. Specifically, hemagglutinin is a protein consisting of three monomeric protein chains. Each monomer consists of three important subdomains called fusion domains, receptor binding domains, and residual esterase subdomains.

Certain type A influenza (H1N1) is representative of hemagglutinin, and N represents neuraminidase. The current influenza A viruses are A (H1N1) and A (H3N2). Influenza A (H1N1), influenza A (H3N2), and influenza B strains are included in the annual vaccine. Influenza A viruses are difficult to control, as they change and make it difficult for the human immune system to detect them. There are two kinds of changes. Treatment and meningococcal disease of meningococcal disease Because meningococcal disease is not biased toward patient infection, it is a big problem in the medical field. I count on it. The success of trying to eliminate this disease is limited. Antibiotics play a role in supporting patients with bacterial meningitis, and steroids have been tested to help reduce risk factors. Prevention is also an important issue as meningitis can spread only by direct contact with infected body fluids. of

Another type of change is called "antigen conversion". Antigen conversion is a sudden large change in influenza type A virus resulting in new hemagglutinin and / or new hemagglutinin and neuraminidase protein in human influenza virus. This transformation results in a virus having a new influenza A subtype or a combination with hemagglutinin or hemagglutinin and neuraminidase which are derived from a different animal population than the same human subtype, It is not immune. Mandatory (eg novel)) virus. This "transformation" occurred in the spring of 2009 when a new genetic combination of the H1N1 virus appeared in infected populations, spread rapidly, and caused a pandemic. When migration occurs, most people have little or no protection against new viruses.