GSK3 Beta

Part 1 Scientific basis for target selection Characterization of Target Diabetes Diabetes mellitus is a group of heterogeneous metabolic diseases characterized by the presence of excess glucose and glucagon in the blood of diabetic patients. The most frequently cited cause of diabetes (DM) is the lack of insulin secretion (type I DM) and / or more generally insulin resistance in peripheral tissues, especially muscle and adipose tissue (type II DM).

Production of intracellular neurofibrillary cells is dependent on intracellular kinases such as glycogen synthase kinase 3 (GSK 3) Lithium reduces hyperphosphorylation of tau by inhibiting GSK 3 in cell culture and transgenic mice It has been shown that 114-116. . By its inhibition of GSK3, lithium also prevents the accumulation of Aβ peptides in the brain of mice overexpressing APP117. This agent may prove beneficial by reducing neurofibrillary tangles and amyloid plaque formation but its toxicity to the elderly may limit its use. According to reports, propionic acid, the second mood stabilizer, inhibits GSK3 and is currently undergoing a trial sponsored by valproate NIA at mild to moderate AD. Hyperphosphorylation of tau and formation of intracellular neurofibrillary tangles can be a major cell death pathway in AD. Inhibitors of this process may be necessary to compensate for the effects of anti-amyloid therapy

Beta decay is a nuclear decay process in which unstable transmutation and particle release are more stable. Beta attenuation has two types - beta minus and beta plus. In both collapses, the nuclei in the nucleus are converted to different kinds of nuclei where the particles are released. Beta negative as well as beta plus collapse penetrate moderately (ie radiation can penetrate deep into solid objects). There is a closely related process called electron capture. There, electrons are confined in the nucleus, acting like β +.

In nuclear physics, beta decay (beta decay) is a radioactive decay in which beta rays (fast energy high energy electrons or positrons) and neutrinos are released from the nucleus. For example, neutron beta decay transforms them into protons by electron emission or conversely converts protons to neutrons by positron emission (positron emission), thereby changing the nuclide type. Before the beta collapse, beta particles and related neutrinos are not present in the nucleus, but they are generated during collapse. Through this process, unstable atoms get a more stable ratio of protons to neutrons. The potential for collapse of nuclides caused by beta and other forms of collapse is determined by their nuclear binding energies. All existing nuclide combinations can form so-called nuclear bands or stable valleys. For energy-enabled electrons or positron emissions, the energy release (see below) or the Q value must be positive.