Growth Hormones

Growth hormone is a very controversial subject in today's society. Hormones give very effective results. In many cases, this is a benefit for users. Studies have shown that growth hormone can help children with short stature. About 1990, growth hormone has become a common solution for premature infants related to normal growth curves. During these years, growth hormone is not approved by adults unless they are seriously damaged by disease, trauma or tumor.

The human growth hormone genes, growth hormone 1 (growth hormone; pituitary growth hormone) and growth hormone 2 (placental growth hormone; growth hormone mutant) are localized to q22-24 region of chromosome 17 and human fluff. This membrane is closely related to somatomammotropin (also known as placental lactogen) gene. GH, human chorionic gonadotropin and prolactin belong to a group of homologous hormones with growth and lactation activity. The major isoform of human growth hormone is a 191 amino acid protein with a molecular weight of 22,124 daltons. This structure contains four helices necessary for functional interaction with GH receptors. Structurally, GH appears evolutionarily homologous to prolactin and chorionic gonadotropin. Despite the apparent structural similarity between growth hormones from different species, only human and old world monkey growth hormone has a significant effect on human growth hormone receptor.

The secretion of growth hormone (GH) in the pituitary gland is controlled by the neurosecretory nucleus of the hypothalamus. These cells release growth hormone releasing hormone (GHRH or growth hormone releasing hormone) and growth hormone repressing hormone (GHIH or somatostatin) into the blood of the pituitary portal vein around the pituitary. The release of GH in the pituitary depends mainly on the balance of the two peptides, which in turn is influenced by many physiological stimuli (eg exercise, nutrition, sleep) and inhibitors secreted by GH (eg free fatty acids) receive.

Growth hormone is a large peptide hormone produced by the anterior pituitary. It is structurally similar to prolactin. Like prolactin, growth hormone is immunostimulatory and inhibited by catecholamines 65. In healthy condition, growth hormone increases protein synthesis, gene transcription, somatic size and mitosis. It reduces uptake and utilization of glucose and promotes differentiation. Growth hormone induces the production of insulin-like growth factor-1 in the liver, which mediates many of the effects of growth hormone