Gene One

In 1996, Don Ruiz and colleagues founded Gene One and competed in the biotechnology industry after discovering genetic technology to eradicate tomato and potato diseases. Because they do not buy vegetables contaminated with chemicals, their innovation has gained popularity from customers. For over eight years, the company has become a $ 400 million company. To keep them growing as well as they grow, their management believes that they should be public; through investment funds, they are working on new research, marketing strategies and advertising campaigns You will receive the funds.

In order to develop an autosomal recessive disorder, we inherit two mutant genes, one for each parent. These diseases usually spread by two carriers. Although their health is rarely affected, they have a mutant gene (recessive gene) and a normal gene (dominant gene). Every pregnancy, two carriers may have 25% unaffected children, two of which may have normal (left) and 50% unaffected children . In the middle), there is a possibility of 25% that the affected child has two recessive genes (right)

This figure shows how the CFTR gene is inherited. One person inherits two copies of the CFTR gene - one copy per parent. If each parent has a normal CFTR gene and an incorrect CFTR gene, each child has a 25% chance of inheriting two normal genes, the probability of inheriting a normal gene and a defective gene is 50% , There is a possibility of 25% Genetic two defective genes

Each person has two copies of each gene and one is inherited from each parent. Most genes are identical, but some genes (less than 1% of the total) differ slightly among individuals. The allele is in the form of the same gene, and its DNA base sequence difference is small. These small differences contribute to the unique physical characteristics of each individual. Scientists track genes by giving them unique names. Gene names can be very long, so symbols are also assigned to genes. This is a short combination of letters (abbreviated as numbers) representing abbreviations of gene names. For example, the gene associated with cystic fibrosis on chromosome 7 is called cystic fibrosis transmembrane conductance regulator, its symbol is CFTR.

Cystic fibrosis is an autosomal recessive disorder - that is, two defective genes (one for each parent) are needed to develop the disease. The gene thought to cause cystic fibrosis is called cystic fibrosis transmembrane conductance regulator or CFTR. This gene is on chromosome 7. The severity and extent of this disease vary widely among patients with cystic fibrosis. Typically, this condition results in an increase in the chloride transport defect and trauma across epithelial cells and the viscosity of body secretions, particularly secretions from the respiratory tract (ie, the lungs, throat) and pancreas. As a result, patients are prone to pancreatic dysfunction and repeated chest infections