Ethical Considerations of Randomized Controlled Trials

The purpose of Chapter 2 is not to investigate general research ethics, but to investigate the ethical issues specifically related to RCT. Discuss the ethical reasons of RCT and the overall ethical issues of RCT design from the viewpoint of social work ethics and research ethics. Implementation of RCT appropriately implemented as an ethical research program requires careful consideration of the following factors: a person who may be morally eligible. When planning and designing RCT, it is necessary to consider research ethics (ie correct implementation of scientific research based on cultural norms, practical ethics and professional ethics). Special consideration has been given in consideration of the increasing use of Internet RCT.

Randomized clinical trials pose several fundamental ethical issues that ethically sensitive researchers must carefully consider. A randomized, double-blind clinical trial is ethically rational and is the preferred way to demonstrate efficacy and safety of treatment. There are alternative methods such as design of crossover law and self-management law, use of historical control law, observation method, clinical trial of practitioner, etc. In some cases take place. The use of a randomized, double-blind, clinical trial must ensure that the patient's research plan is adequately accounted for, record informed consent, adequate safety considerations and acceptable low risk / benefit ratio

A practical randomized controlled trial (RCT) is designed to evaluate the effectiveness of intervention under practical clinical conditions. However, these studies pose ethical issues for researchers and regulators. Our goal is to identify a list of important ethical issues in the practical RCT and highlight the gap in the ethical literature. Our review identified four major themes: 1) the distinction between research practices, 2) the need for consent, 3) the factors that must be disclosed in the consent process, and 4) the research ethics committee's Proper supervision. 1) Most authors refuse to do research with practical RCT - the need to practice differentiation -. They hypothesize that participation in research is less profitable than clinical practice for patients and the hypothesis that risks are greater than clinical practice, but in the case of actual RCTs, neither is hypothesized.

Ethical problems in practical randomized controlled trials: recent literature review identifies gaps in ethical theory

The fundamental differences in evidence-based therapy are observational studies and randomized controlled trials. Observational research types in epidemiology such as cohort studies and case-control studies provide less evidence than randomized controlled trials. In observational studies researchers retrospectively assess the relevance between treatment given to participants and their health status and there may be considerable mistakes in design and interpretation.