Epileptogenesis: GABAA Receptor Subtypes in Human Temporal Lobe Epilepsy

Partial epilepsy is usually caused by brain injury. The onset of epilepsy in this case is called epileptogenesis. I will explain the effects of these changes on the changes in transmission through the GABA (A) receptor during hippocampal attacks and the onset of epilepsy. Epilepsy is a very common disease in 2010, about 0.5 to 1 affected per 100 people. It can happen throughout the lifetime, but it has a high incidence among infants and the elderly. Seizures are usually voluntary, there is no direct cause.

Approximately 50% of epileptic patients suffer from partial epilepsy. Partial epilepsy is usually the origin of the temporal lobe. However, the true morbidity of temporal lobe epilepsy is unknown, since not all temporary temporal lobe epilepsy cases are confirmed by video EEG, most cases only medical history and EEG findings during interstitial phase based on. Approximately 47 to 60% of categorical patients have not had seizures with drugs. After failure of three first-line anti-epileptic drugs (AED), the probability of seizure freedom is 5-10%. ILAE currently has a formal definition of medically refractory / drug resistant epilepsy defined as a patient who has been seizure even if it is fully tested with two antiepileptic drugs. The percentage of surgical non-seizures in carefully selected patients with refractory temporal lobe epilepsy is 70 to 80%.

In this article, we will investigate inner temporal lobe epilepsy with hippocampal hardening, temporal lobe epilepsy with hippocampal hardening, medial temporal lobe epilepsy, MTLE, temporal lobe epilepsy, marginal epilepsy, psychomotor epilepsy, and complicated partial epilepsy I will explain. The foregoing terms may include synonyms, similar obstacles, variations on use, and abbreviations. Medial temporal lobe epilepsy is the most common form of epilepsy, and treatment of epilepsy is the most difficult. Although hippocampal sclerosis is a common pathological basis, other lesions of the medial temporal lobe structure also cause the same electroporation syndrome. The etiology of hippocampal sclerosis and the natural history of medial temporal lobe epilepsy are not completely understood, but if prevention drug trials and interference with seizures follow daily life, see the comprehensive epilepsy center is important.