Epidemiology of Avian Influenza H5N1 Virus

Avian Influenza H5N1, also known as avian influenza H5N1, is a highly pathogenic influenza that is infected mostly in Asian countries, with many poultry and human beings around the world. The epidemic itself of H5N1 spread worldwide is due to the seasonal movement of undiscovered migratory bird infected with H5N1, it can suppress and eradicate a large amount of poultry and illegal trade in developing countries such as Southeast Asia It is because it was not. The first epidemic was a geese bred in Guangdong province in China, in 1997 human infections including 6 deaths and 18 deaths were first reported in Hong Kong.

A highly adaptive pathogenic H5N1 strain (referred to as "HPAIA (H5N1) of" H5N1 subtype A highly pathogenic avian influenza virus ") is an influenza that causes H5N1 influenza, commonly known as" avian influenza "or" avian " Is particularly popular among many birds in Southeast Asia. This lineage of HPAI A (H5N1) spread throughout the world. It is an epidemic (epidemic other than human) and epidemic (especially diseases affecting many kinds of animals in a vast area, killing tens of millions of birds and stimulating hundreds of millions of other birds To do. The slaughterhouse controls its spread. The majority of the media referred to "bird flu", and the majority of H5N1 mention is about this particular stock.

Avian influenza A virus (H5N1) infects human-induced avian influenza. In most cases there is history of sick bird exposure and human-to-human infection. The H5N1 virus is severely infected with intestinal function and respiratory failure. Immunization against seasonal 'fi' can not prevent bird flu sufficiently. Dengue is a mosquito disease caused by Dengue virus, which is usually self limiting in most cases. However, there may be life-threatening complications such as dengue hemorrhagic fever and dengue shock syndrome. Dengue is not contagious and does not spread through physical contacts

Influenza virus infection causes seasonal and pandemic influenza, resulting in significant morbidity and mortality in humans (1). The outbreak of avian influenza by highly pathogenic H5N1 and H7N9 viruses increases the risk of another influenza pandemic (2-4). The genome of influenza A virus (IAV) contains at least eleven proteins including hemagglutinin (HA), neuraminidase (NA), nuclear protein (NP), matrix proteins (M1 and M2), and nonstructural protein (NS1) Code. And NS 2), polymerase proteins (PA, PB 1 and PB 2) and PB 1 - F 2 (5, 6). Anti-influenza antiviral drugs that block the function of viral proteins such as NA and M2 to treat infectious diseases have been developed. However, due to its high variability, several seasonal influenza and avian influenza strains are showing resistance to current antiviral drugs (6 - 8). Therefore, designing a new therapy and identifying the target of infected cells is important for effective influenza control.

Influenza A virus hemagglutinin antagonizes type I interferon (IFN) response by inducing degradation of type I IFN receptor 1