Drug Resistance Rising Among Mycobacterium Tuberculosis Cases

Increased drug resistance in Mycobacterium tuberculosis cases Abstract The drug resistance of patients infected with Mycobacterium tuberculosis improves. In the 1950s miraculous medicines used so far have proven to be useless in many cases. This is simply because bacteria are not sensitive even if you take antibiotics such as isoniazid, rifampicin, pyrazinamide. This pathogen easily spreads through the air and has the ability to attack the respiratory system. This can cause fatal consequences if not treated properly.

The emergence of multidrug resistant tuberculosis bacteria (MDR - TB) and a wide range of resistant tuberculosis bacteria (XDR - TB) is also an important global concern. The MDR-TB strain is resistant to both rifampicin and isoniazid, and this combination of drugs is commonly used for the treatment of tuberculosis. The XDR-TB strain is also resistant to at least one of the fluoroquinolone treated as a second line and the other three drugs (amikacin, kanamycin, or capreomycin), and these patients have few treatment options. . Two pathogens are particularly problematic in immunocompromised individuals, including those with HIV infection. Expression of drug resistance in these strains is usually due to incorrect use of antibacterial agents for treatment of tuberculosis and selection of drug resistance.

Unfinished treatment can have serious consequences, including the onset of persistent infectious and drug resistant Mycobacterium tuberculosis. Due to irregular supply of drugs, inadequate treatment or inadequate compliance, inappropriate treatment results in drug resistance problems. Drug tolerance is a potential threat to TB control programs throughout the world. (8) The research was conducted at the Higher Medical Education Hospital in Pakistan. The research proposal was approved by the hospital ethics review committee. I got an informed consent from the patient. At the hospital, there is a TB clinic with the support of the Pakistan National TB Control Project. Inspection service for microscopic examination and medication treatment protocol based on National Tuberculosis Control Program Agreement