Drug Identification With Gas Chromatography Mass Spectrometry

For a variety of reasons, people use medicines in various ways every day. Because today's society uses a wide variety of drugs, drug testing is the standard for pre-job inspection. Drugs that the user may have examined include cocaine (cracking), amphetamine (crystal), opiates (codeine, morphine, heroin), PCP (phenidine), and hemp. Gas chromatography / mass spectrometry is used to test hair or urine samples from potential drug abusers or candidates. This is the best way to test drug use.

Gas chromatography - mass spectrometry (GC - MS) is a combination of features of gas - liquid chromatography and mass spectrometry to identify different substances in a test sample. GC-MS applications include drug tests, fire surveys, environmental analysis, explosive surveys, and identification of unknown samples. In addition, we can identify trace elements in materials that were previously thought to have been resolved rather than being identified. GC - MS consists of two main components: gas chromatograph and mass spectrometer. Gas chromatograph uses a capillary column that depends on column size (length, diameter, film thickness) and phase properties (eg, 5% phenyl polysiloxane). When the sample moves through the length of the column, the difference in chemistry between the different molecules in the mixture separates the molecules.

Isolation and identification techniques 1. Gas chromatography-mass spectrometry (GC-MS) mass spectrometry is used to determine the identity of unknown volatile compounds or as a mass selective GC detector. We recommend that the MS logo is also supported by other data such as GC retention data, infrared spectroscopy, nuclear magnetic resonance. The MS can operate in ion detection mode (SIM), multi ion mode (MIM) or full scan mode. In SIM or MIM mode, the MS measures ions selected only at very short time intervals during GC running, thus achieving higher sensitivity and higher scanning than full scan detection mode.

Today, gas chromatography / mass spectrometry has become a selection technique for drug separation and analysis. Employers usually conduct drug tests on potential employees. They use samples of potential employee's hair or urine for testing and analyze samples through GC / MS to determine whether potential employees have used that medicine. They determine this by comparing the mass spectrum of the known drug with the mass spectrum of the test sample. Since mass spectrometers are like fingerprints of chemical substances, gas chromatograph / mass spectrometers are considered optimal resources for identification of chemical substances (drugs, etc.).