Disseminated Intravascular Coagulation

To prevent blood flow after injury, the body uses three methods to maintain hemostasis; vasospasm, platelet embolism and coagulation. Coagulation is an important process to prevent blood loss when blood vessels are cut or damaged. Thrombus is a platelet-enhanced embolization by fibrin network. However, people with diffuse intravascular coagulation syndrome (DIC) are not required for thrombus formation throughout the vessel. Organ disorders due to vascular occlusion; Furthermore, coagulation factors and platelets are consumed as necessary, which can cause life threatening bleeding.

I decided to write a paper on clotting system including clot formation, mainly about diffuse intravascular coagulation. Disseminated intravascular coagulation syndrome, also known as DIC, is the pathological activation of the blood coagulation mechanism that may occur in response to various diseases. However, DIC is most common in severe sepsis and septic shock. DIC is not a specific disease but complications and influences due to progress of other diseases and diseases. (Porth, 2011). When the body is injured, certain proteins in the blood are activated, enter the injured site, stop bleeding, and control hemostasis. Hemostasis is a normal process of sealing blood vessels to prevent blood loss and bleeding. It is abnormal if blood is not properly condensed, or if this coagulation is insufficient to stop bleeding.

Disseminated intravascular coagulation syndrome (DIC) is an acquired syndrome (Cunningham, 1999; Huether & McCance, 2008; Wada, 2008) that occurs when stimulation stimulates intravascular coagulation and fibrinolysis to cause imbalanced haemostasis . The onset of DIC begins with the release of tissue factor (TF) from endothelial cells or leukocytes (WBC). TF is present in many different cell types, including lung, brain and placenta. Release of TF occurs after various causes including trauma, ischemia, excessive metabolic stress, exposure to tumors, infectious organisms, cytokines and endotoxins (Baglin, 1996; Vinay, Abul, Nelson, and Richard, 2007). Endotoxin release is a means of inducing DIC in Gram negative sepsis (Vinay et al., 2007). These endotoxins are the structural components of Gram-negative bacteria released during bacterial lysis.