Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy 2010: 3, 275-280. Aerobic training increases skin perfusion by a nitric oxide mechanism in type 2 diabetes

It is well known that many of the locally released vasodilators and vasoconstrictor compounds can affect skin perfusion. In this study, we investigated the effect of aerobic training on nitric oxide (NO), prostaglandin (PG) and endothelium derived hyperpolarizing factor (EDHF) in dorsal skin skin stimulated by type 2 diabetes (T2DM) It was. Ten earlier sedentary elderly patients with T2DM (57.0 ± 1 year old) and nine sedentary controls (53.5 ± 2 years) underwent moderate health training every week for 6 months in a monitored environment Three tests were conducted before and after implementation. All subjects measured the back skin perfusion of baseline (32 ° C.) and thermal stimulation (40 ° C. and 44 ° C.) 1 hour after oral administration of 325 mg of aspirin, which is a known PG synthesis inhibitor, once have started. . Before ingesting aspirin, a subcutaneous microdialysis probe was inserted into each foot and physiological saline (only aspirin-blocking PG pathway of left foot) or L-NAME (N (G) -nitro-1-arginine) was applied. Methyl ester; thereby inhibiting the PG and NO pathway of the right foot). Standard data previously collected on subjects who received saline administration by microdialysis without taking aspirin was used as a control group. It was found that the EDHF pathway alone was not blocked and the reactivity of the maximal perfusion was significantly reduced compared to NO and EDHF unblocked after training. There was no significant difference in the maximum inhibition of NO, PG and EDHF directly attributable to NO when examined according to the target group and the training situation. However, NO, PG, and EDHF contributions to maximal perfusion did not significantly increase, decrease, and change by aerobic training in combination with diabetes and control subjects, respectively, because there were no significant differences between the groups. Maximal Stimulation Caused by Aerobic Training in 6 Months Improvement in dorsal skin perfusion seems to be largely NO based and the contribution of PG after training is small regardless of the condition of diabetes.

However, obesity alone can not account for the overall surge of diabetes. Many obese people do not have evidence of insulin resistance, diabetes or metabolic syndrome. On the other hand, there are patients with type 2 diabetes. This is also evident at the national level. In countries with low obesity rates, the incidence of diabetes is high, the reverse is true. Sri Lankan's obesity rate remained at 0.1% from 2000 to 2010, diabetes increased from 3% to 11%. At the same time, in New Zealand, at the same time, obesity increased from 23% to 34%, but diabetes decreased from 8% to 5%. Sugar consumption can explain this difference very well

Not all overweight people suffer from type 2 diabetes, but insulin resistance exacerbated by obesity is an early metabolic disorder in almost all patients with type 2 diabetes. Metabolic syndrome, the central element of insulin resistance, is thought to be present in more than 25% of the population of the United States, and is thought to be an element of diabetes mellitus 6. Can prevent or delay the onset of type 2 diabetes 7 and 8 medical professionals are faced with the task of identifying high risk groups as early as possible and implementing effective weight loss intervention before diabetes onset I am in

Metabolic syndrome raises the risk of developing type 2 diabetes five-fold. Type 2 diabetes is considered a complication of metabolic syndrome. In people with impaired glucose tolerance or impaired fasting glucose, the presence of metabolic syndrome doubles the risk of developing type 2 diabetes. Pre-diabetes and metabolic syndrome may represent the same disease and are composed of different biomarkers. The presence of metabolic syndrome is associated with higher prevalence of CVD than IGT patients without type 2 diabetes or syndrome. Low adiponectinemia has been shown to increase insulin resistance and is considered a risk factor for the onset of metabolic syndrome