Detection and Treatment of Patients with Severe Sepsis

Pathophysiology of pathophysiological infections, inflammatory response and sepsis (cascade) that leads to septic shock are important areas of interest in the literature. Under normal circumstances, when a pathogen invades a human host and tissue damage occurs, the host initiates an inflammatory response to repair the tissue. The main types of pathogens include viruses, bacteria, and parasites (Porth & Matfin, 2009; Raghavan & Marik, 2006). Cellulitis is an example of an acute infection that typically affects the skin and / or subcutaneous tissue of the lower limbs.

Sepsis is an extreme reaction of the body to infection. The immune system essentially reverses and triggers the systemic inflammatory response. Infections occur from anywhere - pneumonia, skin, or UTI. Septicemia is considered severe sepsis in cases where signs of dysfunction such as dyspnea or abnormally high heart rate are seen in organs. When blood pressure drops to an extremely low level, septic shock persists even with treatment or intravenous infusion. Two days ago, my father exchanged hips with planned surgery. Nobody was aware that his incision was infected. When he came home from the hospital his condition worsened. He began to vomit, fever, and confused - we thought he was at Toronto's house, we left decades ago.

For severe sepsis, immediate treatment of one month or more is required in the intensive care unit. Recovery is possible, but it takes time. It is known that many people return to normal health without severe dysfunction after severe sepsis. In severe sepsis, the duration of the recovery period depends on the number of organs affected by the infection and the extent of organ dysfunction, so it depends on the patient. Approximately 50% of severe sepsis survivors have experienced short- or long-term cognitive and physical problems during recovery and are collectively referred to as post-treatment syndrome. Psychological (anxiety, memory loss), mental difficulty (simple arithmetic calculation is impossible), physical (excessive fatigue, muscle weakness, fullness of breath, chest pain)

Patients with severe sepsis continue to maintain a high mortality rate even after severe sepsis and only 61% survive for 5 years. Their physical physical quality of life was significantly lower than the population standard, but the mental QOL score was only slightly lower than the 5 year population criteria after severe sepsis. Throughout the five-year follow-up period, the results of mortality and quality of life were similar to those of other seriously ill patients. These data should be considered when assessing long-term outcomes and considering the cost-effectiveness of treatment of this patient group.