Current Research on Duchennes Muscular Dystrophy

Current research on Duchenne muscular dystrophy Duchenne muscular dystrophy is the result of a defective gene on the X chromosome. This gene is responsible for the production of muscle protein dystrophin. Anti - dystrophin is a component of the dystrophin - glycoprotein complex that is affected by the forces generated during muscle contraction. In the absence of dystrophin production, no dystrophin-glycoprotein complex (DCG) is present. Because the fascia only sustains muscle contraction, the lack of DCG causes fissure in the fascia.

You will often hear Duchenne Muscular Dystrophy (DMD) and Becker Muscular Dystrophy (BMD) together. BMD is another type of muscular dystrophy with symptoms like Duchenne, but it is a milder form. BMD is also caused by changes in the dystrophin gene, but dystrophin in patients with BMD is abnormal, but effective. This still causes muscle weakness and damage, but it is not as serious as Duchenne

Progression of Becker type muscular dystrophy is very variable and far exceeds Duchenne muscular dystrophy. Yet another form can be regarded as an intermediate between Duchenne and Becker MD (mild DMD or severe BMD). The severity of the disease can be indicated by the age of the patient at the onset of the disease. In one study it is suggested that Becker muscular dystrophy has two different modes of progression. It occurs around 7 to 8 years of age, indicating that heart involvement and stairs are more frequent after age 20. If the onset is around 12 years old, the heart will not be affected so much.

There are various kinds of muscular dystrophy. For example, Duchenne muscular dystrophy, Becker malnutrition, Emery-Dreyfus muscular dystrophy, myotonic dystrophy, limb grid type malnutrition, facial cranial brachial muscular dystrophy, congenital malnutrition, ocular malnutrition and distal muscular dystrophy. Duchenne's malnutrition occurs in 2 out of 10,000 young men. It is the most serious disease of all muscular dystrophies. It mainly occurs in young boys affecting children today. Symptoms and signs of muscular dystrophy include sudden falls, muscles of the calf thighs, difficulty going out when lying or sitting, difficulties in running and jumping, weakness in the muscles of the feet, Mental retardation "and so on.

Becker type muscular dystrophy is similar to Duchenne muscular dystrophy, but it is not so serious. This type of muscular dystrophy is also more common in boys. Muscle weakness occurs mainly in the arms and legs, and symptoms occur between 11 and 25 years old. Other symptoms of Becker type muscular dystrophy are as follows. Symptoms range from mild to severe, but most suffer from congenital muscular dystrophy. People can not stand up to sit or save lives. The life expectancy of this type also depends on the symptoms. Some patients with congenital muscular dystrophy die in infancy, others continue to live until adulthood