Creating an E. Coli Strain to Produce Antivenom

Background The annual population of snakes is 421,000 people, of which 20,000 have died. These injuries are particularly concentrated in developing countries where snake bites are occupational risks. (Kasturiratne et al., 2008). This negative effect can be mitigated by making and producing low cost, human compatible universal antitoxin serum. Lethal toxin neutralizing factor, hereinafter referred to as LTNF, is a substance isolated from the serum of blood and blood of Diorphis vilginiana.

E. coli is a bacterium that inhabits the intestines of humans and animals. Shiga toxin producing E. coli strain or STEC is the cause of most food related E. coli infections. E. coli O157: H7 and other STECs such as E. coli O145 and E. coli O121: H19 produce toxins known as Shiga toxin causing human disease. E. coli does not make livestock and animals like bacteria that carry bacteria in the intestine. E. coli O157: H7 is most common in dairy cows, but chickens, deer, sheep and pigs are also known to carry them. When intestines and feces of infected animals come into contact with corpses, meat will be contaminated during meat processing. Grinded or mechanically softened meat is considered to be more dangerous than whole meat. This is because E. coli can be mixed throughout the meat during the grinding process or during the softening process.

A harmful strain of Escherichia coli produces a substance called Shiga toxin which is harmful to humans. The most common deadly E. coli strains in the US - strains related to multiple outbreaks and deaths in the past few years - are generally E. coli O157: H7 found in cattle. This strain was previously infected with humans by eating uncooked ground beef, and it is best known for its fatal outbreak in 1992. The good news is that most people will recover within 5-7 days, as the immune system will kill nasty bacteria. However, 5-10% of people suffer life-threatening complications called hemolytic uremic syndrome. This syndrome is associated with decreased frequency, fatigue, and kidney damage. This occurred in an incident related to the October epidemic.

E. coli contains several different strains, of which only some cause human disease. E. coli O157: H7 is the strain that causes the most serious diseases. Common sources of E. coli include raw or uncooked hamburgers, unsterilized juice and milk, and fresh foods. This virus is a small capsule much smaller than bacteria and contains genetic material. Virus can cause infection and cause disease. People can spread viruses to each other. The virus is contained in the feces or vomit of the infected person. People infected with viruses may contaminate food and drinks, especially if you do not thoroughly wash your hands after using the toilet.