Clostridium Botulinum

The history of Clostridium botulinum dates back to Europe in the 19th century, which first contaminated sausages, which led to the outbreak of food poisoning botulism. (1-3) In fact, the term botulism is derived from Latin botulism. This means sausage. (1,3) Microbiologist Emile Pierre Marie van Elmengem first described pathogens in 1897, and after an autopsy (1-3) separated the anaerobic bacteria from ham and spleen tissue. Originally known as Botox, it finally renamed botulinum to distinguish it from aerobic spores.

Botulinum neurotoxin was first identified in 1897 and is a product of anaerobic bacteria, botulinum, causing botulism food poisoning. In the 1940's, type A botulinum toxin was purified and isolated in crystalline form. In 1989, the US Food and Drug Administration (FDA) approved type A botulinum toxin as a treatment for strabismus, eyelids, unilateral facial spasm. It is approved for use in cervical dystonia, hyperhidrosis and cosmetic applications. Currently there are more than 30 symptoms, of which type A botulinum toxin is reported to be beneficial.

This product is derived from Clostridium botulinum bacteria. Botulinum toxin is a neurotoxin, its pure form is one of the most powerful biotoxins known. However, when used in cosmetics, application amount is small, it is almost impossible to produce a systemic effect. I rarely can see it. It occurs temporarily when it occurs. Botox is very safe. Local birthmarks, redness, headache are the most common. Symptoms such as influenza and nausea are less common. The most worriing side effect is unintended weakness of upper eyelid muscle. This lasts 2 to 6 weeks and can be reduced with prescribed eye drops

Toxin toxin is thought to be the main component of botulinum toxin. "Botox is a neuromuscular blocker produced by Clostridium botulinum (anaerobic bacteria) that grows in contaminated foods and causes severe muscle paralysis after ingestion The injected form of purified botulinum toxin A small amount can be administered to prevent chemicals called acetylcholine from being released from muscle contractile neurons. "(Mendez-Eastman) Small amounts are very useful for cosmetic applications.