Clone poster girl Dolly the sheep's arthritis was 'normal for her age'

According to a new study, arthritis afflicting Dolly, the first mammal cloned from adult somatic cells, is normal at her age.

Dolly was born in the laboratory. To keep her DNA, scientists exchanged the egg cell nucleus with the adult somatic cell nucleus. Then use the current to initiate cell division and ablate the egg cells to transplant surrogate mother.

Dolly eventually developed pulmonary disease and deteriorated in 2003, but her birth in 1996 became headline news.

Kevin Sinclair, professor of developmental biology at the University of Nottingham in Leicestershire, told The Register, Dolly also had osteoarthritis. About five and a half years old (age of man is about 40 years old), she has problems with her knee, becomes claudication, and has to take anti-inflammatory medicine.

The study published last year by the Sinclair team found that Dolly was very old. Nevertheless, Sinclair said "Dolly's arthritis record is not left."

As she is a clone of a 6-year-old animal, he said that she "prematurely" get "older" is "fear".

In a new study that appeared in today's scientific report, Sinclair and his collaborators analyzed Dolly's bones and four clones from the same cell line. In radiography, it was confirmed that there was mild or moderate osteoarthritis in one patient, but it was similar to the level experienced by a normal sheep at that age.

Dolly's veterinarian, current Edinburgh University, Vice Dean of Tim King University School of Medicine, said the study is "an important contribution to understanding the impact of clones on animal health." Arthritis is "not the result of cloning"

Sinclair admitted that survival at birth and at birth is lower than that of natural pregnancy, he said, "This technique has been a long way since Dolly was born."

His team conducted a "detailed necropsy" of the animals thereafter, and described in particular the aging process, in particular.

In terms of social development and interaction with other sheep, he expressed the clones "perfectly normal" and they also stated that they are "very friendly" for humans. He said that they kept with other sheep, so there was no safety problem. ®

A study of Dolly (a famous sheep clone) showed that her telomeres are shorter in length than her (older) donor, Dolly was younger. Studies on other clones have shown that telomeres in clones are shorter in certain tissues in vivo and are suitable for age in other tissues. Other studies on cloning showed that telomere is suitable for age in all tissues. The length of telomeres has been reported in various studies, but most clones appeared to normally aged. Indeed, the first batch of clones produced so far is living and healthy as of January 2008, 10 years.

Dolly, perhaps the most famous sheep in the world, was living a spoiled life at the Rosslyn Institute. She mates in the usual way and gives birth to ordinary offspring. This indicates that these cloned animals can breed. Born on July 5, 1996, euthanized on February 14, 2003, it was six and a half years old. Sheep can live to 11 or 12 years old, but Dolly suffers from hindlimb arthritis and sheep lung adenomas, a viral lung tumor occurring indoors. On February 2, 2003, the first cloned sheep in Australia suddenly died in 2 and 10 months. The cause of death is unknown, and corpses are quickly cremated by decomposition.

Dolly was cloned by a British scientist in 1996 and died in 2003. According to the science museum's website (www.sciencemuseum.org.uk), "When born in 1997, Dolly Sheep has become scientific meaning.Her relatively early in February 2003 Death triggered long-term cloning research ethics and cloning.Sound discussion "Since it is the occurrence of cloning problems that attracted the attention of the general people, I really want to start a search with Dolly But then, I remembered the human "human body" who claimed that the medieval alchemist often creates. My quest for the history of the clone debate seems to be even more advanced than when I cloned Dolly in 1996.