Characterization of Three Piperine Analogs of Dipeptidyl Boronic Acid

In this study, three piperine analogs (1 to 3) of dipeptidylboronic acid were synthesized. The structure of the synthesized compound was characterized by spectral studies. Antitumor activity of all compounds against 3 cancer cell lines and antibacterial activity against 7 bacterial species and 5 fungal species were screened. The results of in vitro experiments showed that most compounds showed moderate to good inhibitory activity against cancer cell lines tested, Compound 1 showed excellent antitumor activity, Compound 3 showed 62 μg against Aspergillus fumigatus It was found that the concentration was. Effective antimicrobial agent Compared with other test compounds / mL and t

As shown in FIG. 4, the general mechanism of catalysis by acidic substances such as boron trifluoride or sulfuric acid involves protonation of the electrophile to enhance its electrophilicity. The protonated oxo group extracts more electron density from the electrophilic carbon atom and increases the possibility that it is attacked by the nucleophile. Although the general mechanism uses Bronsted acid as a catalyst, the mechanism is similar to a Lewis acid (eg BF 3), but instead of a proton, the oxo group has a different electron deficient center (eg, not filled p). Boron atom trajectory)

In this study, three piperine analogs (1 to 3) of dipeptidylboronic acid were synthesized. The structure of the synthesized compound was characterized by spectral studies. Antitumor activity of all compounds against 3 cancer cell lines and antibacterial activity against 7 bacterial species and 5 fungal species were screened. The results of in vitro experiments showed that most compounds showed moderate to good inhibitory activity against cancer cell lines tested, Compound 1 showed excellent antitumor activity, Compound 3 showed 62 μg against Aspergillus fumigatus It was found that the concentration was. Effective antimicrobial agent Compared with other test compounds / mL and t