CDV - Wikipedia

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Canine distemper virus (CDV) is known to cause apoptosis in vivo and in vitro in the central nervous and lymphoid tissues of infected dogs. CDV-induced apoptosis is usually induced by an extrinsic pathway that disrupts cell function and ultimately activates caspases leading to cell death. In normal cells, CDV first activates caspase-8, which acts as a starting protein and subsequently activates scorpion protein caspase-3. However, apoptosis induced by CDL in HeLa cells does not involve the initiation of protein caspase-8. Apoptosis of HeLa cells induced by CDV follows a different mechanism than the vero cell line. This change in the cysteine ​​protease cascade indicates that CDV induces apoptosis via the intrinsic pathway, except for the need for promoter caspase-8. In contrast, scorpion proteins are activated by the virus rather than the caspase cascade.

Despite its name, Canine Distemper Virus (CDV) is known to infect various species in the order of Carnivora (1). Recently, even nonhuman primates are deadly infected with CDV, causing concern about potential human infection (2). American Zoo captured tiger, lion, leopard, until a series of fatal infection in Jaguar occurs, Felid is considered to be resistant to CDV (3). After that, in 1994, about one - third of Serengeti 's Lion died or disappeared. Their deaths in the Serengeti ecosystem and the deaths of various carnivores are due to CDV (4). Since then, Bobcat, Canada ly, Eurasian ly, is very endangered and are Iberian ly, and cases or occurred in other free-ranging cats, such as the Amur Tiger is now you have occurred (5-8). The reason for "overflow" to this new host is the growing interest in research.