Cardiac Stem Cell Therapy and the Promise of Heart Regeneration

Stem cell therapy for heart disease is an exciting but controversial research field. Strategies such as cell transplantation and reprogramming have yielded interesting and conscious results. However, with the progress of clinical trials, there are several unresolved issues, such as the mechanism of cardiomyocyte turnover and the optimal treatment strategy to achieve clinical efficacy, so that our imperfect stem cell behavior Understanding becomes clear. In this article we will examine how cardiac stem cell biology will lead to clinical trials. And in order to achieve true heart regeneration in patients, it may be necessary to address important issues in experimental cardiac regeneration.

Whether cardiac stem cells (CSC) are differentiating into cardiomyocytes (cardiac tissue) is the best way to regenerate and replace myocardium. Heart Stem Cells z 2012, Cochrane Collaboration; this is an organization that analyzed 33 studies, including 1,765 patients injected into the heart to analyze medical research and improve heart pumping ability. - 1. List three major pairs of muscles. What is a pair of muscles? Muscles are usually divided into two groups called muscle pairs. When a pair of muscles contracts, the other muscles relax and move. The human body is composed of many different muscles, but some are more important than others

Recent studies have shown that stem cell therapy targets cardiac regeneration in cardiovascular disease. The use of stem cells in therapeutic devices and methods can result in efficient and rapid myocardial regeneration and ultimately can affect cardiovascular morbidity and mortality. There are different types of stem cells, such as embryonic stem cells, adult stem cells, and induced pluripotent stem cells for CVD treatment (Table 1). Previous studies have shown that embryonic stem cells differentiate into cardiomyocytes and endothelial cells differentiate into hearts derived from myocardial infarction, umbilical cord blood-derived MSC of dilated cardiomyopathy, bone marrow derived MSCs of cell formation, and iPSC and iPSC The proliferative effect of vascular progenitor cells, endothelial progenitor cells (EPC) and cardiac stem cells of myocardial infarction

Embryos for cardiac repair and adult stem cells are an active area of ​​research. Many cells including adult bone marrow derived cells including embryonic stem (ES) cells, cardiac stem cells naturally present in the heart, myoblast cells (muscle stem cells), tissue mesenchymal cells (bone marrow derived cells, these cells) Stem cell type endothelial progenitor cells (endothelial cells, which produce vascular lining) and umbilical cord blood cells such as muscle, bone, tendons, ligament and adipose tissue have been studied as possible sources for regenerating damaged cardiac tissue I came. All of these have been investigated in mouse and rat models, and some have been tested with larger animal models such as pigs.