Cardiac regeneration

Research on cardiac repair and regeneration shifts from the focus of stem cells to the dynamic interaction of stromal cells and immune cells within the cardiac stroma. This review provides new insight into their complex network of cardiac stromal cell immunomodulation and interactions and highlights the possibility of treating heart disease.

This review summarizes the current understanding of the role of the Hippo-YAP pathway in cardiac development, growth, homeostasis, disease, and regeneration, especially on the role of the Hippo-YAP pathway in endogenous myocardial regeneration, including important pathways in regulation We are paying attention to the role. Role of cardiomyocyte proliferation, differentiation, stress response and mechanical signaling

The epicardium is a pluripotent cardiac precursor tissue which is an important signal center for the generation and repair of the heart. This review explains the recent advances in our understanding of epicardial biology and discusses the possibility of using epicardial properties to develop a strategy for cardiac repair and regenerative therapy .

Regulatory T cells (Tregs) proliferate during pregnancy and promote tolerance to the fetus. Here, the authors show that Treg induces proliferation of fetal and maternal cardiomyocytes during pregnancy and promotes myocardial repair via proliferation-promoting paracrine effect.

Cardiomyocyte proliferation is central to the cardiac regeneration process and several processes have shown that a series of organisms capable of complete regenerative reactions regulate proliferation when damaged. The inflammatory response closely regulates the good balance between proliferation and repair. Extracellular matrix deposition after injury creates an acceptable environment for cell proliferation and is affected by epicardial signal after injury. FGF and PDGF signaling induces new blood production, provides oxygen and nutrient supply to regenerating tissue, and a new study highlights the need for regenerative nerves

Research on cardiac repair and regeneration shifts from the focus of stem cells to the dynamic interaction of stromal cells and immune cells within the cardiac stroma. This review provides new insight into their complex network of cardiac stromal cell immunomodulation and interactions and highlights the possibility of treating heart disease. This review summarizes the current understanding of the role of the Hippo-YAP pathway in cardiac development, growth, homeostasis, disease, and regeneration, especially on the role of the Hippo-YAP pathway in endogenous myocardial regeneration, including important pathways in regulation We are paying attention to the role. Role of cardiomyocyte proliferation, differentiation, stress response and mechanical signaling

One of the most controversial topics in heart revival research over the past 20 years is the presence of endogenous stem cells. Several types of endogenous cardiac progenitor cells (or stem cells) (CPC) have been reported to be present in the adult heart and can be distinguished by the surface marker c-Kit, Sca1, or PDGFRα (platelet derived growth factor receptor α) I will. Transcription factor Isl 1; Hoechst dye outflow; or the ability to form cardiac spheres during culture (13 - 16). Overall, the cost per click is rare and heterogeneous in terms of origin and apparent behavior, which partly explains the surrounding technical issues and controversies related to nearly all reports of its reproductive potential To do. Although cultured CPC shows some degree of system plasticity, it is not clear whether this can accurately mimic in vivo behavior.