Brain Transplant: An End to Parkinsonism?

Modern brain grafting: the end of Parkinson's disease or the beginning of a big debate. It sometimes begins with drowsiness, "getting into trouble", or shaking (1). Perhaps it started with a little finger cramps that was not there before. Words are harder and softer up to the level of whispering; this is usually accompanied by hypersensitivity. The movement becomes hard, becomes unstable, and becomes slow (2). Trembling occurred with trembling hands, arms, legs, chin, and face. After that, usually you can walk only in a short shuffle step, you lose balance and instability (3).

Brain transplantation is the continuation of The Frozen of the Frozen Addict which is the announcement of Nova in 1986. In the early movies, drug users were paralyzed or "frozen" with strange diseases. I can not explain the symptoms of Parkinson's disease until the doctor tracks it to a contaminated batch of synthetic heroin. In this latest version, Nova is following two addicts in Sweden who are undergoing treatment that is not available in the United States. Other treatments including levodopa and adrenal cell transplantation were discussed. The ethics of fetal tissue research is also being debated

Earlier this year, the research team at Oxford Parkinson's Disease Center developed a new method to identify drugs that may be reused for Parkinson's disease. The team used stem cell technology to create dopamine-producing brain cells from skin cells of the same Parkinson's disease patients as Parkinson's disease patients. They compared the genetic activity of these cells to brain cells grown by unconditional people and focused on some important differences. The researchers then searched the database to change the activity of cells of Parkinson's disease to drugs that may not be affected, drugs that may be suitable for Parkinson's disease, such as drugs Did.

Scientists are interested in the potential of stem cells to produce new brain cells for Parkinson's disease for a while. Recently, a method for converting normal adult cells (eg, skin cells) into stem cells (abbreviated as induced pluripotent stem cells or iPSc) was developed. From there, these stem cells can become a type of dopamine, thereby losing brain cells in this state. To test the performance of the cells, researchers used brain scan. They found that the cells function like normal dopamine-producing brain cells and successfully produce dopamine. Later on, they were able to confirm that the transplanted cells survived, and more importantly they were integrated into existing neural networks - part of the brain functions of the primates It will be

In the 1980s, some people suffering from Parkinson's disease injected fetal dopamine neurons into the brain to replace what was lost. After 14 years their brains were examined after death. Some transplanted neurons contain Lewy bodies, suggesting that alpha synuclein can move between cells. This is currently thought that Parkinson's disease spreads throughout the brain. In a three year study, the team will study a mouse model that accurately models Levy's physical activity in brain cells. They will study how ruby ​​bodies influence brain cells, send electrical signals, release dopamine, and control movement. They also carefully observe the change in this situation over time.