Brain Disorders: Blood Brain Barrier

From the viewpoint of economic responsibility and human suffering, brain damage is a major concern of modern society and the number of elderly people is increasing due to long life. The main challenge in the treatment of many neurodegenerative diseases is the presence of the polarized layer of endothelial cells including the blood brain barrier (BBB), which prevents the systemic administration of the drug from entering the brain tissue. Currently, more than 98% small molecules and over 100% macromolecular drugs can not cross the blood brain barrier unless destroyed or relaxed by disease 1a so effective treatment is possible.

However, Maddy Hornig, an epidemiologist specializing in neuropsychiatric medicine at Columbia University's Mellman School of Public Health, explained that "the blood-brain barrier is inevitable, it is not completely protected" I will. "Some parts of the brain are not protected at all like the hypothalamus.If there is something that can open the blood brain barrier open the door Antibody can get in the brain and find its target "From the background, the behavioral response to physical illness is intuitive. When we are infected with influenza, we feel it physically and emotionally. We are not on the list, I am frustrated, I have no appetite. High fever, usually a sign of extreme inflammation, can cause dizziness and hallucinations. Boris Sakyki, neuroscientist at McMaster University in Canada, says: "Behavior is the ultimate measure of the situation elsewhere." "If you have flu, your mood will change."

Brain Brain Burquest Your brain needs a protected environment to function properly. A special barrier called the blood brain barrier will help maintain this environment. It has specialized cells that affect almost all brain capillaries. In the rest of your body, most capillary membranes have pores. But in your brain capillaries are closely connected and covered with a fat barrier called the "glia pod". This sheath is coming from a nearby astrocyte called astrocyte. Drugs leaving the capillary of the brain must pass through the capillary wall itself (as the capillary does not pass through), and the membrane of the astrocytes reach the cells in the brain. As a general rule, the rate at which a drug enters the brain depends on its lipid (fat) solubility.