Botulinum Toxin Type B (MYOBLOC) Versus Botulinum Toxin Type A (BOTOX) Frontalis Study: Rate of Onset and Radius of Diffusion

Background Botox type A and type B can improve the appearance of facial wrinkles. Differences between time to onset and epidemic have been observed, but no direct comparative study has been done.

Comparison of efficiency and spreading radius of botulinum toxin type A and B in wrinkles at a target price

Method Adults with symmetrical moderate to severe wrinkles at full contracture receive botulinum toxin type A (BOTOX; 5 U) on one side of the forehead and type B (MYOBLOC; 500 U ). A computer analysis photograph taken at rest and a complete frontalis muscle contracture were created, and a time lapse movie was created. Diffusion radius and time to maximum effect

As a result, botulinum toxin type B functions slightly faster than type A. All patients responded quickly to type B, but some patients delayed type A response, B type botulinum toxin continued to observe a larger spreading radius and the area of ​​wrinkles decreased with the dose used.

Conclusions In this comparative study of patients with symmetrical forehead wrinkles, Botox type B results in a larger diffusion zone and faster onset than type A.

One unit of MYOBLOC (botulinum toxin type b) corresponds to the calculated median lethal dose of intraperitoneal dose (LD 50) in mice. This assay was specifically performed for the production of MYOBLOC (botulinum toxin type B) by Solstice Neurosciences. Due to the details of various mouse LD50 assays (eg, vectors, dilution protocol, laboratory protocol), it is not possible to combine MYOBLOC's biologically active unit (botulinum toxin type B) with other botulinum toxins or other toxin units. Comparisons or transformations to units are assessed by other specific assays. Thus, the difference in species sensitivity to different botulinum neurotoxin serotypes eliminates dose-activity relationships in animals from human dose estimates. The specific activity of MYOBLOC (botulinum toxin type B) is in the range of 70 to 130 units / ng

Adults with symmetrical moderate to severe wrinkles at the time of complete contracture receive botulinum toxin type A (BOTOX; 5 U) on one side of the forehead and type B (MYOBLOC; 500 U) on the other side, . A computer analysis photograph taken at rest and a complete frontalis muscle contracture were created, and a time lapse movie was created. Measure the diffusion radius and the time until the maximum effect comes out. Botulinum toxin type B functions slightly faster than type A. All patients responded quickly to type B, but some patients delayed type A response, B type botulinum toxin continued to observe a larger spreading radius and the area of ​​wrinkles decreased with the dose used.

Botulinum toxin type B (MYOBLOC) and botulinum toxin type A (BOTOX) Frontal muscle study: Incidence and diffusion radius

MYOBLOC (botulinum toxin type b) is provided as a colorless transparent to pale yellow sterile injectable solution in a 5 mL glass vial. Each one-time preparation of the MYOBLOC vial contains 5,000 units of botulinum toxin type B, 0.05% human serum albumin, 0.01 M sodium succinate and 0.1 M sodium chloride, pH about 6. Unit MYOBLOC (b type meat) toxic toxin corresponds to the calculated median lethal dose of intraperitoneal dose (LD 50) in mice. This assay was specifically performed for the production of MYOBLOC (botulinum toxin type B) by Solstice Neurosciences. Due to the details of various mouse LD50 assays (eg, vectors, dilution protocol, laboratory protocol), it is not possible to combine MYOBLOC's biologically active unit (botulinum toxin type B) with other botulinum toxins or other toxin units. Compare or convert units using other specific measurement methods