Blood Agents Throughout History

Historical blood broker The use of chemical weapons during the war has been in use for the first time. The first use of chemical warfare dates back to 600 BC, and Greek soldiers will poison their enemy's reservoir. Spartan soldiers attacked Greece with sulfur in 423 BC. Later, in 673 AD, the Greek Navy gained bad reputation by notoriously burning chemical substances in the high seas. Throughout the Middle Ages, the use of chemical weapons continued until Mongolian troops used Catapult to throw burning sulfur to their enemies.

Hemostatics are granules, powders and impregnated dressings used to increase blood clotting and to stop faster severe bleeding. They were used in various ways throughout the 20th century, from the use of hemostatic gels and patches used in surgery to the more common types used in today's emergencies. QuikClot is a popular brand that has undergone many changes since entering the market. It was originally finely pulverized powder that poured into the wound. The mixture absorbs moisture from the blood, concentrates the remaining blood components, and increases blood coagulation. Early formulations caused a very strong thermal response in the wound, which resulted in more pain and damage to the surrounding tissues. Delicate and powdered quality also causes problems caused by the fact that it is sprayed on wet hands or even in the eyes of healthcare workers.

Thrombolysis is a thrombus or thrombus segmentation by injection of a thrombolytic agent (a drug that degrades thrombus, the main component of the thrombus) (Tiziani, 2013). The role of thrombolytic agent is due to activation of fibrin. Lysozyme forms the proteolytic enzyme plasmin, which adheres to fibrin and degrades the clot (Tiziani, 2013; Catangui & Slark, 2012); this process is called clot decomposition. For example, Alteplase and Reteplase are fibrin-specific recombinant tissue plasminogen activator (r-tPA) drugs, Tenecteplase, a recombinant tissue plasmin original activator (tPA) that adheres to fibrin-bound plasminogen, In contrast, streptokinase is a nonspecific plasminogen activator that binds fibrin-bound plasmin. (Tiziani, 2013; Catangui & Slark, 2012) Pro and unbound plasminogen (Tiziani, 2013).