Bioethics’s Hot Topic of Growth Hormones

Author Ronald Berry said that the Food and Drug Administration (FDA) has decided to introduce a growth hormone to provide treatment plans to short stature people And approved the use of. Bailey also acknowledges that bioethics is a controversial topic in the medical field. Bioethics includes research on "ethical problems in medicine and research" (Kaplan). Bailey is involved in the subject of bioethics, as it involves the use of growth hormone, especially human growth hormone (HGH).

The human growth hormone genes, growth hormone 1 (growth hormone; pituitary growth hormone) and growth hormone 2 (placental growth hormone; growth hormone mutant) are localized to q22-24 region of chromosome 17 and human fluff. This membrane is closely related to somatomammotropin (also known as placental lactogen) gene. GH, human chorionic gonadotropin and prolactin belong to a group of homologous hormones with growth and lactation activity. The major isoform of human growth hormone is a 191 amino acid protein with a molecular weight of 22,124 daltons. This structure contains four helices necessary for functional interaction with GH receptors. Structurally, GH appears evolutionarily homologous to prolactin and chorionic gonadotropin. Despite the apparent structural similarity between growth hormones from different species, only human and old world monkey growth hormone has a significant effect on human growth hormone receptor.

The secretion of growth hormone (GH) in the pituitary gland is controlled by the neurosecretory nucleus of the hypothalamus. These cells release growth hormone releasing hormone (GHRH or growth hormone releasing hormone) and growth hormone repressing hormone (GHIH or somatostatin) into the blood of the pituitary portal vein around the pituitary. The release of GH in the pituitary depends mainly on the balance of the two peptides, which in turn is influenced by many physiological stimuli (eg exercise, nutrition, sleep) and inhibitors secreted by GH (eg free fatty acids) receive.

Growth hormone is a large peptide hormone produced by the anterior pituitary. It is structurally similar to prolactin. Like prolactin, growth hormone is immunostimulatory and inhibited by catecholamines 65. In healthy condition, growth hormone increases protein synthesis, gene transcription, somatic size and mitosis. It reduces uptake and utilization of glucose and promotes differentiation. Growth hormone induces the production of insulin-like growth factor-1 in the liver, which mediates many of the effects of growth hormone