B and T Cells in Bone Marrow and Thymus

B cells and T cells begin to develop in the bone marrow and share the following steps in their early development: Myeloid pluripotent hemocyte stem cells (HSCs) self-renew or express CD117. It binds to the stem cell factor on the bone marrow stroma surface and shows the difference between HSC and multipotent progenitor cell 1. The next step of re-sharing is the expression of RAG1 / RAG2, which is necessary for T cell and B cell receptor development and turns the cells into early lymphoid progenitor cells (ELP) 1.

T cells and B cells are lymphocytes, whereas T cells mature in the thymus and B cells mature in the bone marrow. The key to T cells is that they are defenders that are activated in the thymus and do not actually produce antibodies, but help protect them in other ways. They have antigen-recognizing helper T cells, in particular macrophages which proliferate and form chemicals (interferons) and which then form helper cells which stimulate the formation of b cells. They then stimulate the proliferation of killer cells. Killer cells produce and destroy abnormal somatic cells, release proteins called perforin that form pores in the cell membrane they attack, and water and ions from the surrounding environment flow into the cell and rupture them . This is called melting. Inhibition of cell inhibition after pathogen destruction, and memory t cells survive for long periods and stimulate memory b cells to produce antibodies. This is a secondary B cell response

T lymphocytes belong to the leukocyte group and are produced in adult bone marrow. In the thymus, they mature into cells that recognize themselves from non-autologous cells. T cells have a characteristic structure that allows pathogens to bind to their surface - as well as suitable locks for specific binding