Autism spectrum disorder causes, mechanisms, and treatments: focus on neuronal synapses

1 Korea Advanced Institute of Science and Technology, Department of Biology, Ota, Korea

Autism Spectrum Disorder (ASD) is a group of developmental disorders characterized by impairment of social interaction and communication and restricted repetitive interest / behavior. With the progress of the human genome, a number of genetic mutations related to ASD have been identified. There are an increasing number of studies to quickly validate these relationships using various methods including mouse genetics. These studies also have identified important mechanisms of ASD pathogenesis, many of which involve synaptic dysfunction, and investigated new, mechanism-based treatment strategies. This review will attempt to integrate three key aspects of ASD research: human genetics, animal models, and possible treatments. Continued efforts in this area ultimately reveal core mechanisms for most cases of ASD and identify neurological mechanisms associated with specific ASD symptoms and important for effective ASD treatment Provide clues.

Autism Speaks is dedicated to funding research reasons, focusing on the prevention of autism, treatment, healing, improvement of recognition of autistic spectrum disorders, and advocacy of autistic patients and their families It is the largest autistic science and advocacy group. In addition to supporting autistic treatment networks, autism genetic resource exchange, autistic clinical trial networks, autism organization programs, and a variety of other scientific and medical programs, autism affects each year new I'm talking about clinical study. The fund exceeded $ 30 million. For more information on autism, please visit www.autismspeaks.org.

Autism occurs at different ages, it is very important to understand the causes, effects, and solutions of the disease. Autism is a persuasive developmental disorder (PDD). It leads to a delay in the development of basic skills (Autism Spectrum). Symptoms of this disease usually appear before 3 years of age. Symptoms range from mild to severe symptoms (Autism Spectrum). Autism is affected by 1 out of 88 children and 1 out of 54 boys. The proportion of children with this sickness is increasing. - ... The answer to these questions is still unknown. A widely accepted theory is that there are many factors that increase the risk of autism, and in most cases only one factor need not be condemned. Most researchers believe that it is related to brain structure and function abnormality. Prenatal and birth problems have been shown to increase the risk of autism

Scientists do not clearly understand the cause of Autism Spectrum Disorders. There are several factors that may cause autism. It includes genetic factors or environmental factors at birth. If you have a family with autism, your child has a higher risk of developing autism. Research indicates that this is not caused by poor child rearing or vaccination. Although children usually do not heal or exceed autism, the study showed that early diagnosis and treatment can improve the symptoms. There is no single cure for autism. Treatment includes a version of intensive capacity development and leadership instruction called Applied Behavior Analysis (ABA), and a more interactive, child-centered behavioral therapy version. Treatment includes special training and support for parents, speech therapy, occupational therapy, and / or social skills training.