Anticancer Properties of Piper Betle Leaves Active Compounds

Colorectal cancer is the third most common cancer in the world (World Cancer Research Foundation). Colonoscopy, chemotherapy, radiation therapy and biologic therapy are the most common treatments for colorectal cancer. These treatments can be used alone or in combination. One of the most commonly used drugs for the treatment of colorectal cancer is 5-fluorouracil (5-FU). 5 - FU is a cell cycle specific S phase dependent fluorinated pyrimidine analog (Yim et al., 2006). Due to its short biological half-life, it is always used in combination with other drugs to increase the effectiveness of that drug.

Broccoli is rich in glucosides and can degrade into biologically active compounds with anticancer properties. These compounds protect cells from DNA damage, inactivate carcinogens, induce tumor cell death, prevent tumor angiogenesis, and provide anti-inflammatory effects. Pumpkin is abundant in beta carotene and converted into vitamin A in the body Vitamin A is an antioxidant that protects against free radical damage. Beta-carotene, which makes oranges orange retard cancer growth, can promote enzyme secretion, and can help to eliminate cancer carcinogens.

Several plant anticancer and anti-inflammatory compounds are currently identified. Scientific experiments are being conducted on the anticancer action of plants and their ingredients. Herbs are the basis for the treatment and treatment of various diseases and physiological conditions such as Ayurveda, Unani, Siddha. However, no systematic research has been done to evaluate the efficacy and safety of plant-derived formulations. No attempt has been made to isolate and identify the active ingredients involved in these actions.

Researchers at Cornell University believe that the combination of phytochemicals (collectively called phytochemicals) is mainly contained in the apple skin, with most fruit anticancer and antioxidant activity It is suggesting. They believe that the synergistic action of these phytochemicals has superior health benefits over single compounds such as vitamin C, vitamin E and beta carotene which have been extensively studied for their antioxidant activity I will. Using colon carcinoma cells treated with apple extract, Liu et al. Found that 50 mg of apples extracted from the skin reduced cancer cell proliferation by 43%, while extracts from the same amount of apple meat reduced cancer cell growth 29 . % Similarly, 50 mg of extract from skin containing apple reduced hepatoma cell proliferation by 57% compared to 40% for samples taken from apple without skin.