Ankylosing Spondylitis: A Long Time Rheumatic Disese

Exercise and non-steroidal anti-inflammatory drugs (NSAIDs) have been the center of symptom management for many years (Sieper and Braun 2011). However, until recently there was a lack of cure to ameliorate this disease (Khan, 1995). NSAIDs are often used frequently and are ineffective for some patients (Miceli-Richard and Dougados 2002). They are sufficient to alleviate pain, increase spinal movement, and improve motor performance, but they appear to have little effect on underlying inflammatory processes (Van der Horst-Bruinsma et al .

Ankylosing spondylitis (AS) is a life-long symptom that can cause damage and swelling of the spinal joint. Although the etiology of ankylosing spondylitis is unknown, a strong genetic association is considered to be a major cause of ankylosing spondylitis. Most people with spondylitis have a gene called HLA-B27. People with this gene are prone to spondylitis, but the signs of this gene are not seen in 10% of people. So the exact cause of illness is a difficult task.

The cause is unknown, but most medical experts believe that this disease is related to genetic factors. About 90% of patients with ankylosing spondylitis have HLA-B27 gene. However, only about 1% of individuals with this gene suffer from ankylosing spondylitis. The study also found a link between ARTS1 and IL23R genes and ankylosing spondylitis. These two genes are thought to play a role in the immune function causing inflammation. Researchers are currently investigating how these genes affect ankylosing spondylitis and are studying how inflammation occurs and persists

HLA-B 27 typing: blood test to determine if the HLA-B 27 gene is present. This gene is a genetic marker related to high risk of developing spinal arthritis, such as ankylosing spondylitis. Most children with this gene are healthy, but they may develop this type of arthritis more than others. Your child can test negative and still diagnose this arthritis. Immune System: Complex biochemical system of your body that protects you from bacteria, viruses, scratches and other injuries. Many components of this system include a variety of cells (such as T cells), organs (such as lymph glands), chemicals (such as histamine and prostaglandins).