Amyotrophic Lateral Sclerosis

Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig disease, is the most common motor neuron disease in adulthood (Batos et al., 2011). Because motor neurons are cells that transmit information from the brain to the muscles, they can contract. During ALS, these motor neurons gradually degenerate and die (Ingram, 2012). Symptoms progress from muscle weakness, clumsiness, paralysis (Ingram, 2012). It then begins with limbs, erodes the ability to move slowly, ending sputum, starting to affect languages, swallowing and finally breathing (Ingram, 2012).

/ Amateur Lateral Sclerosis (ALS) Papers: Genetic aspects of amyotrophic lateral sclerosis: Doctor / June / Jan / Ph.D. Institutiion: Clinical Research Center, Queens Land University (UQCCR) Day 2014 Contents: Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease that can lead to the loss of nerve cells controlling movement. Death due to respiratory failure leads to progressive weakness. In Australia, about 2000 people live in ALS at any time, and around 400,000 people worldwide are diagnosed with ALS. The cause of amyotrophic lateral sclerosis is not clear. Although most ALS is sporadic (SALS), about 10% of ALS patients are familial (FALS) with autosomal dominant inheritance pattern, because the second generation only acquires abnormal genes from the parent It means good. In these theories that take over the disease, the influence of genetic risk factors has attracted a great deal of attention.

K. E; Dupre, N. Swingler, R. Purcell, S. Hayward, C. A 50 bp deletion of the superoxide dismutase 1 (sod 1) promoter reduces the expression of sod 1 in vitro and may be related to increased age of onset of sporadic amyotrophic lateral sclerosis. Amyotroph Lateral Sc 2008, 9, 229 - 237

The name of amyotrophic lateral sclerosis comes from Greek. "A" in muscle atrophy means "no", "Myo" means muscle, "nutrition" means nutrition. Literally, "There is no muscle nutrition." When muscles contract, muscle is wasted. "Side" identifies areas within the human spine where a portion of neurons controlling the signal and muscle are located. As the region deteriorates, it causes hardening ("hardening") of the region. (Www.alsa.org) As motor neurons degenerate, they no longer send impulses to the muscles that normally cause muscle movement. The first signs and symptoms of amyotrophic lateral sclerosis tend to be overlooked as they are less noticeable. The first few symptoms include stiffness, cramping, muscle cramps, weakness. Victims of amyotrophic lateral sclerosis may have language disabilities that are difficult to chew and swallow later.