Alzheimer’s Disease Using a Mouse Model: Genotyping and Behavioral Studies

Alzheimer's disease (AD) is the most common form of age-related dementia. It was first explained more than 100 years ago, but little is known about how or when the disease process begins. According to the latest report, 2 million Americans live with AD (Fargo & Bleiler, 2014). The characteristic / diagnostic part of the disease is due to a decline in the cognitive ability of the patient, and the accumulation of amyloid plaques and neuritic plaques and neurofibrillary tangles. Unlike other cognitive dysfunctions, AD affects various classes of neurons (Selkoe, 2001).

Alzheimer's disease is an acquired cognitive and behavioral disorder, which is unknown and may progress to dementia. Potential progressive memory loss is most common in Alzheimer's disease patients. Many treatments for Alzheimer's disease have been explored. The main Alzheimer's disease drugs are centrally acting cholinesterase inhibitors. - "Blood safety in the AIDS era" reflects the history of transfusion, the prophylaxis and donation efforts of the clean (ill) blood transfusion, especially the emergence of acquired immune deficiency syndrome (AIDS) virus . AIDS epidemics that attack blood banks is not only considered an urgent problem but also a warning to doctors and patients who need blood transfusion frequently or naturally.

Researchers work hard to find effective drugs for Alzheimer's disease. However, so far, no studies have shown that effective herbal substitutes can improve the cognitive function of Alzheimer's disease. Recent studies have tested apple juice, but the study showed that it only improves the behavior of people with Alzheimer's disease rather than cognitive symptoms. The results of our clinical trials are very promising. It shows improvement of various elements of cognitive function in elderly patients with Alzheimer's disease who were taking Bacopa monnieri for 6 months. We noticed that we used a very coarse but simple cognitive function measurement (MMSES). However, as this is the first test to test Bacopa monnieri for Alzheimer's disease patients, we believe that it will provide valuable data for further detailed research.

Bioengineer Patrick Hsu launched a laboratory in Salk Institute of Biology, La Jolla, California in 2015; his goal is to use monkey cell culture and genetic editing to simulate Alzheimer's disease and Parkinson's disease It was. Neurodegenerative Disease Although this might be more effective to summarize the human behavior and disease progression than the mouse model, before CRISPR - Cas 9 it is too expensive and slow to imagine. He designed the experiment to genetically manipulate his first CRISPR - Cas 9 Martar, but Hsu noticed that this method might just be a foothold for the next step. "The technology will come and go, you can not marry it," he said. "You should always consider the biological problems you need to solve."