Alternatives of Effective Drug Delivery to the Brain

The development of drug carriers and delivery systems to increase delivery to the brain has been the subject of many research tasks both now and hereafter. Most methods for enhancing drug delivery to the brain are focused on avoiding one major obstacle, the blood brain barrier (BBB). The blood-brain barrier consists primarily of brain capillary endothelial cells and is a highly selective barrier of endogenous and exogenous substances (Lai et al., 2013). In fact, about 98% of small molecule drugs and almost 100% of macromolecules do not cross the blood brain barrier (Orive et al., 2009).

And provide drugs in the brain. In brain tumors delivery of anticancer drugs is difficult due to the presence of BBB acting as a physical and physiological barrier to drug delivery to the brain. In addition, cancer chemotherapy can be used for various brain tumors including lymphoma, medulloblastoma, germ cell tumor, and glioma (Thakur, Gahane, Bhadoriya, Jain S., Jain R., and Mishra ). For treatment, they always form high or low risk factors. One of the risk factors that patients can experience is ionization of radiation with high doses of X-rays. Direct ionizing radiation to the head and high-dose x-rays increase the risk to the patient. Whatever the risk of treating the disease

The effect depends on the medicine. Brain scanning shows the brain's response to various medications and the long-term differences of those taking these medications. The most common aspects of the affected brain are the production of neurotransmitters (brain messengers), chemicals related to joy and pleasure (dopamine and serotonin), and prefrontal cortex (planning, decision making, self expression and regulation It is involved in). Social Behavior Many studies indicate that children and adolescents who abuse drugs are at greater risk. For example, a child who started drinking before 15 years old may be poisoned four times as often as at the age of 21. Puberty is important for the development of our brain. That is why we often extend our own personality, improve skills, and take on new responsibilities. In the meantime our brains are constantly mature and constantly changing to have the plasticity and experience of what we have learned.