Acute Myeloid Leukemia

When a person is diagnosed with acute myelogenous leukemia, they have many good problems. Questions such as how the disease works or what the science behind the medical condition is. How dangerous is this disease? What is the type of AML and its differences? Which treatment plan is most effective? But perhaps the most useful question is "How difficult is it to cure it?" One of the easiest ways to measure the severity of acute myeloid leukemia is to define it.

Leukemia: There are basically four main types of leukemia. These are acute myeloid leukemia, acute lymphocytic leukemia, chronic myeloid leukemia and chronic lymphocytic leukemia. This type is usually formed in the bone marrow or tissue that is part of blood cells and is called blood cancer.

Children with Down's syndrome suffer from more than 10 to 15 times more blood cancers. In particular, acute lymphoblastic leukemia is 20 times more common, acute myeloid leukemia of megakaryocytic type (acute megakaryoblastic leukemia) is seen 500 times more. Acute megakaryoblastic leukemia (AMKL) is a precursor of megakaryocytic leukemia, a megakaryocyte that forms platelets. Down syndrome acute lymphoblastic leukemia accounts for 1 to 3% of all pediatric ALL cases. The most frequent occurrence is when you are over 9 years old or when the white blood cell count exceeds 50,000 microliters. It is rare for people under 1 year old. In people without DS, DS ALL brings worse results than other ALL cases

"Acute myelogenous leukemia" occurs in all ages and is a common form of acute leukemia. Certain chromosomal abnormalities in acute myeloid leukemia are translocations between chromosomes 15 and 17 and translocations between chromosomes 8 and 21. In the chromosomal translocations of 15 and 17, the PML gene on chromosome 15 is fused to the retinoic acid receptor alpha gene (RARα). Acute myelogenous leukemia with this type of translocation is therefore well treated with all-trans retinoic acid and results in a good prognosis. In addition, the core-associated transcription factors encoding the genes CBFα and CBFβ are involved in translocation between chromosome 8 and chromosome 21. Another form of chromosomal rearrangement in acute myelogenous leukemia is the inversion of chromosome 16, which also involves the CBFβ gene.