Acute Lymphoblastic Leukemia

Regardless of what happens, any kind of cancer can become painful. But when you hear that a child is being diagnosed, the person's heart seems to be deeper. Several forms of cancer may occur in childhood. The most common is acute lymphocyte / lymphocytic leukemia (ALL). Indeed, it is very common between 0 and 14 years of age, it is called pediatric acute lymphoblastic leukemia (Kanwar, 2013). . (). In the United States, about 3,000 new cases of childhood ALL are reported each year (Kanwar, 2013).

In August, the FDA approved studylecleucel for acute lymphoblastic leukemia. Tisagenlecleucel is an adoptive cell transplantation therapy for B cell acute lymphoblastic leukemia; removal of T cells from someone with cancer, genetic engineering to prepare specific T cell receptors to respond to cancer (chimeric T Cell receptor or CAR-T ") and deliver it to the patient T cells are designed to target proteins called CD 19. This is the first gene therapy approach approved in the US 10 In month, a similar treatment called axicabgene ciloleucel was approved for non - Hodgkin 's lymphoma.

Until this summer, children with recurrent fatal cancers or refractory B-cell acute lymphoblastic leukemia (ALL) had major treatment routes of mass chemotherapy followed by stem cell transplantation. However, of the approximately 2,500 children in the United States receiving these treatments, about 600 people did not respond. In July of this year, the US Food and Drug Administration approved Kymriah (tisagenlecleucel), the first gene therapy, which is a one-time CAR-T cell therapy for children with ALL. This serious prognosis began to change. Change them in the laboratory to attack cancer cells, then inject them into the patient

Acute lymphoblastic leukemia (ALL) is the most common type of infantile leukemia. It also affects adults, especially adults over 65 years of age. Standard therapy includes chemotherapy and radiation therapy. The survival rate varies with age. 85% for children and 50% for adults. Subtypes include precursor B acute lymphoblastic leukemia, precursor T acute lymphoblastic leukemia, Burkitt leukemia and acute double phenotype leukemia. Chronic lymphocytic leukemia (CLL) most commonly develops in adults over 55 years of age. It sometimes happens to young adults, but it has little effect on children. Two-thirds of the affected people are men. The five-year survival rate is 75%. This is incurable, but there are many effective treatments. One subtype is B-cell lymphoblastic leukemia, a more aggressive disease