Academic Outcomes in Individuals With Childhood-Onset Epilepsy: Mediating Effects of Working Memory.

Learning disorders are common in children with epilepsy, but little is known about the effects of various epilepsy-related and cognitive variables. Since sustained seizures have an adverse effect on academic work and work memory can predict academic ability, we investigated the impact of recent seizures and working memory on reading, spelling, and arithmetic of words of children with epilepsy. We assume that sustained seizures are associated with a decline in working memory, which in turn leads to a decline in academic performance.

Our sample included 91 children with epilepsy who were treated in a pediatric hospital in Toronto, Canada, who received a neuropsychological examination to determine candidate for surgery between 2002 and 2009 It is included. Follow-up examinations were performed in surgery (n = 61) and non-surgery (n = 30) patients 4 to 11 years later. Definition of the seizure state is the presence or absence of a seizure in the past 12 months.

For children with refractory epilepsy, impairment of working memory is a major obstacle to the development of learning skills. Intervention of working memory can be a useful aid to academic treatment in this group to promote academic progress. (JINS, 2017, 23, 594 to 604)

In this study, we investigated the accumulation of Aβ in the brain of individuals without epilepsy who are consistent with children with epilepsy. This study was conducted in a cohort of famous population-based epilepsy patients of the Turco adult childhood epilepsy (TACOE) study, tracked from childhood through the latter half of the 1960s. Cerebral amyloid accumulation was examined using positron emission tomography (PET) and amyloid ligand carbon 11-labeled Pittsburgh Compound B (PiB). We hypothesized that people with pediatric epileptic seizures, especially those with the APOEε4 allele, show increased cerebral cortical uptake and hypothesized that they are more likely to develop progressive neurodegenerative diseases such as Alzheimer's disease.

RESULTS In this group-based case-control study, finally adults with pediatric epilepsy were prospectively followed for over 50 years of onset and corresponding series of controls, particularly for children with epilepsy, especially APOE ε 4 4 Medium Late Positron Increased cerebral amyloid burden as measured by tomographic tomography Design, environment and participants from 41 adults in the population-based epileptic patient population in southwest Finland and 46 matched group-based controls were assigned amyloidoses I received a carbon carbon 11-labeled Pittsburgh Compound B (PiB). Positron emission is scanned after long-term predictive follow-up PiB uptake is quantified as the area of ​​cerebellar cortex ratio. In order to study the spatial distribution of amyloid deposits visually assess the uptake of the tracer and analyze the whole brain of the brain by voxel

The 15-year follow-up study of the Connecticut epilepsy study evaluated the prospective cohort study of the community for newly diagnosed children with epilepsy, long-term social consequences. Complications of young adults with childhood epileptic seizures (abnormal neurological findings, abnormal stroke, epilepsy, mental retardation (ID; IQ <60) or history of neurological damage due to stroke) seizures with healthy sibling controls And compared. Age, gender, and matching adjusted Generalized Linear Model According to complex seizure stratification and estimation of a five-year seizure free state, the adjusted odds ratio (aOR) and 95% confidence interval